Remission of Psychosis in Treatment-Resistant Schizophrenia following Bone Marrow Transplantation: A Case Report

Remission of Psychosis in Treatment-Resistant Schizophrenia following Bone Marrow Transplantation: A Case Report

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The authors present the case of a 24-year-old male with simply southern cat shirt treatment-resistant schizophrenia, with predominant severe delusion and hallucination, who received bone marrow transplantation (BMT) for acute myeloid leukemia.After BMT, he showed a remarkable reduction in psychotic symptoms without administration of neuroleptics.He also showed drastic improvement in social functioning.

Follow-up evaluations 2 and 4 years after BMT showed persistent significant improvement of the psychotic state and social functioning.Recent findings show that the major underlying pathogenic mechanism of schizophrenia is immune dysregulation.Thus, conceptually, BMT, a cellular therapy, that facilitates the counteractive processes of balancing inflammation by immune regulation, could produce beneficial clinical read more effects in patients with treatment-resistant schizophrenia.

Further studies are required to define the true benefits of BMT for the possible curative treatment of schizophrenia.